Mutational analysis of conserved residues of the beta-subunit of human farnesyl:protein transferase.

Abstract

The roles of 11 conserved amino acids of the beta-subunit of human farnesyl:protein transferase (FTase) were examined by performing kinetic and biochemical analyses of site-directed mutants. This biochemical information along with the x-ray crystal structure of rat FTase indicates that residues His-248, Arg-291, Lys-294, and Trp-303 are involved with… (More)

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@article{Kral1997MutationalAO, title={Mutational analysis of conserved residues of the beta-subunit of human farnesyl:protein transferase.}, author={Astrid M. Kral and Ronald E Diehl and S. Jane Desolms and Theresa M. Williams and N E Kohl and Charles A. Omer}, journal={The Journal of biological chemistry}, year={1997}, volume={272 43}, pages={27319-23} }