Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus.

@article{Hutchinson2008MutationalAO,
  title={Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus.},
  author={Edward C Hutchinson and Martin David Curran and Eliot K. C. Read and Julia R. Gog and Paul Digard},
  journal={Journal of virology},
  year={2008},
  volume={82 23},
  pages={
          11869-79
        }
}
The genomic viral RNA (vRNA) segments of influenza A virus contain specific packaging signals at their termini that overlap the coding regions. To further characterize cis-acting signals in segment 7, we introduced synonymous mutations into the terminal coding regions. Mutation of codons that are normally highly conserved reduced virus growth in embryonated eggs and MDCK cells between 10- and 1,000-fold compared to that of the wild-type virus, whereas similar alterations to nonconserved codons… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 75 CITATIONS, ESTIMATED 57% COVERAGE

Genome packaging in influenza A virus.

VIEW 15 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

Filamentous influenza viruses.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A supramolecular assembly formed by influenza A virus genomic RNA segments

  • Nucleic acids research
  • 2012
VIEW 6 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Release of filamentous and spherical influenza A virus is not restricted by tetherin.

  • The Journal of general virology
  • 2012
VIEW 3 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 14 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

Selective incorporation of influenza virus RNA segments into virions.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Three-factor cross of influenza virus.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Mutational analyses of packaging signals in influenza virus PA , PB 1 , and PB 2 genomic RNA segments

B. Broni
  • J . Virol .
  • 2008

Similar Papers

Loading similar papers…