Mutational analysis of baculovirus phosphatase identifies structural residues important for triphosphatase activity in vitro and in vivo.

@article{Martins2002MutationalAO,
  title={Mutational analysis of baculovirus phosphatase identifies structural residues important for triphosphatase activity in vitro and in vivo.},
  author={A. Martins and S. Shuman},
  journal={Biochemistry},
  year={2002},
  volume={41 45},
  pages={
          13403-9
        }
}
  • A. Martins, S. Shuman
  • Published 2002
  • Biology, Medicine
  • Biochemistry
  • Baculovirus phosphatase (BVP) and mammalian capping enzyme (Mce1) are members of the RNA triphosphatase branch of the cysteine phosphatase superfamily. Although RNA triphosphatases have a core alpha/beta fold similar to other cysteine phosphatases, there is little conservation of primary structure outside of the cysteine-containing P-loop motif, HCxxxxxR(S/T), that comprises the active site. However, there is extensive primary structure conservation between members of the RNA triphosphatase… CONTINUE READING
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