Mutational analysis of arginine 276 in the leucine-loop of human uracil-DNA glycosylase.

@article{Chen2004MutationalAO,
  title={Mutational analysis of arginine 276 in the leucine-loop of human uracil-DNA glycosylase.},
  author={C L Chen and Dale W Mosbaugh and Samuel E Bennett},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 46},
  pages={48177-88}
}
Uracil residues are eliminated from cellular DNA by uracil-DNA glycosylase, which cleaves the N-glycosylic bond between the uracil base and deoxyribose to initiate the uracil-DNA base excision repair pathway. Co-crystal structures of the core catalytic domain of human uracil-DNA glycosylase in complex with uracil-containing DNA suggested that arginine 276… CONTINUE READING