Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding

Abstract

Muscle acylphosphatase (AcP) is a small protein that folds very slowly with two-state behavior. The conformational stability and the rates of folding and unfolding have been determined for a number of mutants of AcP in order to characterize the structure of the folding transition state. The results show that the transition state is an expanded version of… (More)
DOI: 10.1038/14890

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