Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.

@article{Pause1992MutationalAO,
  title={Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.},
  author={Arnim Pause and Nahum Sonenberg},
  journal={The EMBO journal},
  year={1992},
  volume={11 7},
  pages={2643-54}
}
eIF-4A is a translation initiation factor that exhibits bidirectional RNA unwinding activity in vitro in the presence of another translation initiation factor, eIF-4B and ATP. This activity is thought to be responsible for the melting of secondary structure in the 5' untranslated region of eukaryotic mRNAs to facilitate ribosome binding. eIF-4A is a member… CONTINUE READING