Mutational analysis of PI3K/AKT signaling pathway in tamoxifen exemestane adjuvant multinational pathology study.

@article{Sabine2014MutationalAO,
  title={Mutational analysis of PI3K/AKT signaling pathway in tamoxifen exemestane adjuvant multinational pathology study.},
  author={Vicky S. Sabine and Cheryl L Crozier and Cassandra L. Brookes and Camilla Drake and Tammy Piper and Cornelis J. H. van de Velde and Annette Hasenburg and Dirk G{\"u}nter Kieback and Christos J. Markopoulos and Luc Y Dirix and Caroline S Seynaeve and Daniel William Rea and John M. S. Bartlett},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2014},
  volume={32 27},
  pages={2951-8}
}
PURPOSE Deregulation of key PI3K/AKT pathway genes may contribute to endocrine resistance in breast cancer (BC). PIK3CA is the most frequently mutated gene in luminal BC (35%); however, the effect of mutations in helical versus kinase domains remains controversial. We hypothesize that improved outcomes occur in patients with estrogen receptor–positive (ER positive) BC receiving endocrine therapy and possessing PIK3CA mutations. MATERIALS AND METHODS DNA was extracted from 4,540 formalin-fixed… CONTINUE READING
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