Mutational analysis of Noxa gene in human cancers.

  title={Mutational analysis of Noxa gene in human cancers.},
  author={Sug Hyung Lee and Young Hwa Soung and Jong Woo Lee and Hong Sug Kim and Jong Heun Lee and Jik Young Park and Yong Gu Cho and Chang Jae Kim and Su Young Kim and Won Sang Park and Sang Ho Kim and Jung Young Lee and Nam Jin Yoo},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  volume={111 6},
There has been mounting evidence that dysregulation of apoptosis is involved in the mechanisms of cancer development and somatic mutations of apoptosis-related genes have been reported in human cancers. Noxa, a Bcl-2 homology 3 (BH3)-only member of the Bcl-2 family, is known to interact with anti-apoptotic Bcl-2 family members and induces apoptosis. The aim of this study was to explore the possibility that the Noxa gene is mutated in human cancers. We have analyzed the entire coding region and… CONTINUE READING