Mutational analysis of MAdCAM-1/alpha4beta7 interactions reveals significant binding determinants in both the first and second immunuglobulin domains.

@article{Green1999MutationalAO,
  title={Mutational analysis of MAdCAM-1/alpha4beta7 interactions reveals significant binding determinants in both the first and second immunuglobulin domains.},
  author={Nick Green and J Rosebrook and Nancy E. Cochran and Kemin Tan and Jerry Hsueh-ching Wang and Timothy A Springer and Michael J. Briskin},
  journal={Cell adhesion and communication},
  year={1999},
  volume={7 3},
  pages={167-81}
}
The selective emigration of blood born leukocytes into tissues is mediated, in part by interactions of Ig-like cell adhesion molecules (IgCAMs) expressed on vascular endothelium and their cognate ligands, the leukocyte integrins. Within mucosal lymphoid tissues and gastrointestinal sites the mucosal vascular addressin. MAdCAM-1 is the predominant IgCAM, mediating specific lymphocyte homing via interactions with its ligand on lymphocytes, the integrin alpha4beta7. Previous studies have shown… CONTINUE READING