Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas.


AIMS Evasion of apoptosis is a feature of cancer cells. As a mechanism of apoptosis inactivation in cancer cells, somatic mutations of pro-apoptotic genes have been reported in many cancers. Caspase-10 is an initiation-phase caspase, and somatic mutation of CASP10 that encodes caspase-10 has been found in non-Hodgkin's lymphoma and gastric carcinoma… (More)
DOI: 10.3109/00313020903434371


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