Mutational analysis identifies a five base pair cis-acting sequence essential for GBP130 promoter activity in Plasmodium falciparum.

@article{Horrocks1999MutationalAI,
  title={Mutational analysis identifies a five base pair cis-acting sequence essential for GBP130 promoter activity in Plasmodium falciparum.},
  author={Paul Horrocks and Michael Lanzer},
  journal={Molecular and biochemical parasitology},
  year={1999},
  volume={99 1},
  pages={77-87}
}
Here we describe the functional characterization of a Plasmodium falciparum promoter region, identifying a discrete five base pair sequence element that is responsible for efficient promoter activity. This sequence element binds nuclear factors in a sequence-specific manner. It shares no homology with any known eukaryotic transcription factor binding site, supporting the notion that the protozoan parasite P. falciparum has evolved a transcriptional machinery distinct from that of its human and… CONTINUE READING

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It shares no homology with any known eukaryotic transcription factor binding site , supporting the notion that the protozoan parasite P. falciparum has evolved a transcriptional machinery distinct from that of its human and mosquito hosts .
It shares no homology with any known eukaryotic transcription factor binding site , supporting the notion that the protozoan parasite P. falciparum has evolved a transcriptional machinery distinct from that of its human and mosquito hosts .
It shares no homology with any known eukaryotic transcription factor binding site , supporting the notion that the protozoan parasite P. falciparum has evolved a transcriptional machinery distinct from that of its human and mosquito hosts .
It shares no homology with any known eukaryotic transcription factor binding site , supporting the notion that the protozoan parasite P. falciparum has evolved a transcriptional machinery distinct from that of its human and mosquito hosts .
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