Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments.

@article{Liang2008MutationalAO,
  title={Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments.},
  author={Yuying Liang and Taoying Huang and Hinh Ly and Tristram G. Parslow},
  journal={Journal of virology},
  year={2008},
  volume={82 1},
  pages={229-36}
}
The influenza A virus genome consists of eight negative-sense RNA segments that must each be packaged to produce an infectious virion. We have previously mapped the minimal cis-acting regions necessary for efficient packaging of the PA, PB1, and PB2 segments, which encode the three protein subunits of the viral RNA polymerase. The packaging signals in each of these RNAs lie within two separate regions at the 3' and 5' termini, each encompassing the untranslated region and extending up to 80… CONTINUE READING