Mutational activation of a Galphai causes uncontrolled proliferation of aerial hyphae and increased sensitivity to heat and oxidative stress in Neurospora crassa.

  title={Mutational activation of a Galphai causes uncontrolled proliferation of aerial hyphae and increased sensitivity to heat and oxidative stress in Neurospora crassa.},
  author={Qi Yang and Katherine A Borkovich},
  volume={151 1},
Heterotrimeric G proteins, consisting of alpha, beta, and gamma subunits, transduce environmental signals through coupling to plasma membrane-localized receptors. We previously reported that the filamentous fungus Neurospora crassa possesses a Galpha protein, GNA-1, that is a member of the Galphai superfamily. Deletion of gna-1 leads to defects in apical extension, differentiation of asexual spores, sensitivity to hyperosmotic media, and female fertility. In addition, Deltagna-1 strains have… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 20 references

Photoreception in Neurospora crassa: correlation of reduced light sensitivity with flavin deficiency.

Proceedings of the National Academy of Sciences of the United States of America • 1981
View 2 Excerpts
Highly Influenced

Differential peroxyl radicals regulate carotenoid biosynthesis in Phaffia rhodo - expression of glucose - regulated ( grp 78 ) and heat - shock - inducible zyma

W. A. Schroeder, E. A. Johnson, +3 authors L. Rensing
Mol . Cell . Biol . • 1998

Mutants Efficient transformation of Neurospora crassa by utilizing hybrid of Neurospora crassa defective in regulation of blue light percep - plasmid DNA

E. A. Craig
Proc . Natl . Acad . Sci . USA Mol . Gen . Genet . • 1997

The Aspergillus FlbA Gi family

D. C. Vann
EMBO J . • 1996

required in higher concentrations for growth of cells at higher The G a i homologue gna - 1 controls multiple differentiation path - temperatures

K. A. Borkovich
Mol . Biol . Cell • 1996
View 2 Excerpts

A Saccharo - oxidative stress sensitivity , spontaneous mutation rate and re - myces cerevisiae UAS element controlled by protein kinase A acti - sponse to mutagens

G. Marchler, H. Ruis

Identification of a G codes a protein kinase

H. N. Torres, M. Plamann, D. J. Ebbole, C. Yanofsky
Biochem . Biophys . Res . Commun . • 1993

Mechanism of action of biological antioxidants . A simple and sensitive saturation assay method for the measure -

M. S. Kritsky, T. A. Sokolovsky, +5 authors G. Macino
Proc . Soc . Exp . Biol . Med . • 1992