Mutational Spectrum Drives the Rise of Mutator Bacteria

Abstract

Understanding how mutator strains emerge in bacterial populations is relevant both to evolutionary theory and to reduce the threat they pose in clinical settings. The rise of mutator alleles is understood as a result of their hitchhiking with linked beneficial mutations, although the factors that govern this process remain unclear. A prominent but… (More)
DOI: 10.1371/journal.pgen.1003167

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