Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.

@article{Walker2015MutationalSC,
  title={Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.},
  author={Brian A Walker and Eileen Mary Boyle and Christopher P Wardell and Alex Murison and Dil B Begum and Nasrin M Dahir and Paula Zuzanna Proszek and David C Johnson and Martin F Kaiser and Lorenzo Silva Melchor and Lauren I. Aronson and Matthew Scales and Charlotte Pawlyn and Fabio Mirabella and John Edward Jones and Annamaria Brioli and Aneta Mikul{\'a}{\vs}ov{\'a} and David A. Cairns and Walter Martin Gregory and Ana Quartilho and Mark Trehane Drayson and Nigel Russell and Gordon Cook and Graham Hunter Jackson and Xavier Leleu and Faith Elizabeth Davies and Gareth J Morgan},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2015},
  volume={33 33},
  pages={3911-20}
}
PURPOSE At the molecular level, myeloma is characterized by copy number abnormalities and recurrent translocations into the immunoglobulin heavy chain locus. Novel methods, such as massively parallel sequencing, have begun to describe the pattern of tumor-acquired mutations, but their clinical relevance has yet to be established. METHODS We performed whole-exome sequencing for 463 patients who presented with myeloma and were enrolled onto the National Cancer Research Institute Myeloma XI… CONTINUE READING
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