Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers

@article{Bardelli2003MutationalAO,
  title={Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers},
  author={Alberto Bardelli and D. Williams Parsons and Natalie Silliman and Janine Ptak and Steve Szabo and Saurabh Saha and Sanford D. Markowitz and James K. V. Willson and Giovanni Parmigiani and Kenneth W. Kinzler and Bert Vogelstein and Victor E. Velculescu},
  journal={Science},
  year={2003},
  volume={300},
  pages={949 - 949}
}
Tyrosine kinases (TKs) are central regulators of signaling pathways that control differentiation, transcription, cell cycle progression, apoptosis, motility, and invasion ( [1][1] ). Although a few TK genes have been shown to be mutationally altered in specific human cancers ( [1][1] ), it is not 
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How Mixed Lineage Kinase 3 regulates different MAPK pathways, cancer cell growth and survival, apoptosis, and host's immunity is described and how MLK3 inhibitors can potentially be used along with immunotherapy for different malignancies are discussed.
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