Mutational Analysis of the Structure and Localization of the Nucleolus in the Yeast Saccharomyces cerevisiae

@article{Oakes1998MutationalAO,
  title={Mutational Analysis of the Structure and Localization of the Nucleolus in the Yeast Saccharomyces cerevisiae },
  author={Melanie Oakes and J Aris and J. S. Brockenbrough and H C Wai and Loan Vu and Masayasu Nomura},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={143},
  pages={23 - 34}
}
The nucleolus in Saccharomyces cerevisiae is a crescent-shaped structure that makes extensive contact with the nuclear envelope. In different chromosomal rDNA deletion mutants that we have analyzed, the nucleolus is not organized into a crescent structure, as determined by immunofluorescence microscopy, fluorescence in situ hybridization, and electron microscopy. A strain carrying a plasmid with a single rDNA repeat transcribed by RNA polymerase I (Pol I) contained a fragmented nucleolus… CONTINUE READING
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Laboratory Course Manual for Methods in Yeast Genetics

  • F. Sherman, G. R. Fink, J. B. Hicks.
  • Cold Spring Harbor Laboratory, Cold Spring Harbor…
  • 1986
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