Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.

@article{Czabotar2011MutationTB,
  title={Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.},
  author={Peter E. Czabotar and Erinna F. Lee and Geoff V Thompson and Ahmad Z. Wardak and Walter Douglas Fairlie and Peter M. Colman},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 9},
  pages={7123-31}
}
Pro-survival members of the Bcl-2 family of proteins restrain the pro-apoptotic activity of Bax, either directly through interactions with Bax or indirectly by sequestration of activator BH3-only proteins, or both. Mutations in Bax that promote apoptosis can provide insight into how Bax is regulated. Here, we describe crystal structures of the pro-survival proteins Mcl-1 and Bcl-x(L) in complex with a 34-mer peptide from Bax that encompasses its BH3 domain. These structures reveal canonical… CONTINUE READING

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