Mutation spectra in supF: approaches to elucidating sequence context effects.

@article{Canella2000MutationSI,
  title={Mutation spectra in supF: approaches to elucidating sequence context effects.},
  author={K A Canella and Michael M. Seidman},
  journal={Mutation research},
  year={2000},
  volume={450 1-2},
  pages={61-73}
}
Shuttle vectors carrying the supF suppressor tRNA gene were originally developed for mutagenesis experiments in primate and human cells. Since then, the supF gene has been used as a mutation reporter in other mammalian cells, yeast, Escherichia coli, and transgenic mice. The widespread use of the vector for studies of many DNA reactive agents has produced a large database of mutation spectra. These provide primary information on the kinds and distribution of mutations provoked by many agents… CONTINUE READING

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