Mutation-selection models of coding sequence evolution with site-heterogeneous amino acid fitness profiles.

@article{Rodrigue2010MutationselectionMO,
  title={Mutation-selection models of coding sequence evolution with site-heterogeneous amino acid fitness profiles.},
  author={Nicolas Rodrigue and Herv{\'e} Philippe and Nicolas Lartillot},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 10},
  pages={4629-34}
}
Modeling the interplay between mutation and selection at the molecular level is key to evolutionary studies. To this end, codon-based evolutionary models have been proposed as pertinent means of studying long-range evolutionary patterns and are widely used. However, these approaches have not yet consolidated results from amino acid level phylogenetic studies showing that selection acting on proteins displays strong site-specific effects, which translate into heterogeneous amino acid… CONTINUE READING

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