Mutation-selection balance, dominance and the maintenance of sex.

@article{Chasnov2000MutationselectionBD,
  title={Mutation-selection balance, dominance and the maintenance of sex.},
  author={Jeffrey R. Chasnov},
  journal={Genetics},
  year={2000},
  volume={156 3},
  pages={1419-25}
}
A leading hypothesis for the evolutionary function of sex postulates that sex is an adaptation that purges deleterious mutations from the genome, thereby increasing the equilibrium mean fitness of a sexual population relative to its asexual competitor. This hypothesis requires two necessary conditions: first, the mutation rate per genome must be of order one, and, second, multiple mutations within a genome must act with positive epistasis, that is, two or more mutations of different genes must… CONTINUE READING

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