Mutation selection and the natural history of cancer

@article{Cairns1975MutationSA,
  title={Mutation selection and the natural history of cancer},
  author={John Jr. Cairns},
  journal={Nature},
  year={1975},
  volume={255},
  pages={197-200}
}
Survival of the rapidly renewing tissues of long-lived animals like man requires that they be protected against the natural selection of fitter variant cells (that is the spontaneous appearance of cancer). This article discusses three possible protective mechanisms and shows how they could explain various features of the natural history of certain common cancers of man. 

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> It is clear that the experimental evidence supporting many currently popular hypotheses concerning mutational processes is quite inadequate. > > ([Drake 1970][1]) LITTLE excuse is needed for

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Molecular tumor clocks to study the evolution of drug resistance.

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Causality and Chance in the Development of Cancer.

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