Mutation screening of RET proto-oncogene in a family with medullary thyroid carcinoma, marfanoid habitus and pheochromocytoma; from clinically MEN2B to genetically MEN2A syndrome

Multiple endocrine neoplasia type 2 (MEN2) is sub-classified into three syndromes: MEN2A; MEN2B; and familial medullary thyroid cancer (FMTC). MEN2A is characterized by pheochromocytoma, medullary thyroid carcinoma (MTC), and hyperparathyroidism because of primary parathyroid hyperplasia. MEN2B shares the inherited predisposition to MTC and pheochromocytoma… CONTINUE READING