Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects.

@article{Glaab1997MutationRA,
  title={Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects.},
  author={Warren E. Glaab and Kenneth R. Tindall},
  journal={Carcinogenesis},
  year={1997},
  volume={18 1},
  pages={
          1-8
        }
}
Spontaneous mutation rates at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus were measured in human cancer cell lines defective in the mismatch repair (MMR) genes hMLH1, hPMS2, or GTBP, as well as in a cell line carrying mutations in both hMLH1 and hPMS2. The mutation rate was determined by quantitating mutant frequency increases within a single culture as a function of cell division. These MMR-deficient cell lines exhibited a 50- to 750-fold increase in mutation rate relative… CONTINUE READING

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