Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice.

  title={Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice.},
  author={Dorothy Concepcion and Kevin L Seburn and Gen Wen and Wayne N. Frankel and Bruce A Hamilton},
  volume={168 2},
Chemical mutagenesis of the mouse is ongoing in several centers around the world, with varying estimates of mutation rate and number of sites mutable to phenotype. To address these questions, we sequenced approximately 9.6 Mb of DNA from G1 progeny of ethylnitrosourea-treated mice in a large, broad-spectrum screen. We identified 10 mutations at eight unique sites, including six nonsynonymous coding substitutions. This calibrates the nucleotide mutation rate for two mutagenesis centers, implies… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
48 Citations
11 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 48 extracted citations


Publications referenced by this paper.
Showing 1-10 of 11 references

Effects of ENU dosage on mouse of the mouse genome

  • K. Lindblad-Toh, E. Birney, +6 authors M. Abril
  • Nature
  • 2000

Supermutagenicity ofcalling of automated sequencer traces using phred . I . Accuracy ethylnitrosourea in the mouse spot test : comparisons with methylni - assessment

  • L. B. Base-Russell, C. S. Montgomery
  • Genome Res .
  • 1982

Some recent studies bear - mouse embryonic stem cells

  • N. H. Horowitz, U. Leupold
  • Proc . Natl . Acad . Sci . USA
  • 1951
1 Excerpt

Similar Papers

Loading similar papers…