Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice.

@article{Concepcion2004MutationRA,
  title={Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice.},
  author={Dorothy Concepcion and Kevin L Seburn and Gen Wen and Wayne N. Frankel and Bruce A Hamilton},
  journal={Genetics},
  year={2004},
  volume={168 2},
  pages={953-9}
}
Chemical mutagenesis of the mouse is ongoing in several centers around the world, with varying estimates of mutation rate and number of sites mutable to phenotype. To address these questions, we sequenced approximately 9.6 Mb of DNA from G1 progeny of ethylnitrosourea-treated mice in a large, broad-spectrum screen. We identified 10 mutations at eight unique sites, including six nonsynonymous coding substitutions. This calibrates the nucleotide mutation rate for two mutagenesis centers, implies… CONTINUE READING
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