Mutation of thyroid hormone receptor-β in mice predisposes to the development of mammary tumors

@article{Guigon2011MutationOT,
  title={Mutation of thyroid hormone receptor-β in mice predisposes to the development of mammary tumors},
  author={C{\'e}line J. Guigon and Dong Sung Kim and Mark C. Willingham and S-y Cheng},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={3381-3390}
}
Correlative data suggest that thyroid hormone receptor-β (TRβ) mutations could increase the risk of mammary tumor development, but unequivocal evidence is still lacking. To explore the role of TRβ mutants in vivo in breast tumor development and progression, we took advantage of a knock-in mouse model harboring a mutation in the Thrb gene encoding TRβ (ThrbPV mouse). Although in adult nulliparous females, a single ThrbPV allele did not contribute to mammary gland abnormalities, the presence of… CONTINUE READING

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