Mutation of threonine 422 to glutamic acid mimics the phosphorylation state and alters the action of deltamethrin on Cav2.2

@inproceedings{Symington2007MutationOT,
  title={Mutation of threonine 422 to glutamic acid mimics the phosphorylation state and alters the action of deltamethrin on Cav2.2},
  author={Steven B. Symington and Richard K. Frisbie and Hyo-Jeong Kim and J. Marshall Clark},
  year={2007}
}

• Steven B. Symington, Richard K. Frisbie, +1 author J. Marshall Clark
• Published 2007
• DOI:10.1016/j.pestbp.2007.01.007

Abstract Effects of deltamethrin on voltage-sensitive calcium channels (VSCC) from rat brain (Ca v 2.2) expressed in Xenopus oocytes were assessed electrophysiologically. Deltamethrin reduced peak current of wild-type Ca v 2.2 in a stereospecific and concentration-dependent manner with an EC 50 of 1 × 10 −9  M. Phosphorylation of threonine 422 enhances voltage-sensitive calcium current, increases the probability that Ca v 2.2 will open under depolarizing conditions and antagonizes the… CONTINUE READING

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