Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability.

Abstract

Mutations in genes coding for succinate dehydrogenase (SDH) subunits are believed to contribute to cancer and aging, but the mechanism for this is unclear. Hamster fibroblasts expressing a mutation in SDH subunit C (SDHC; B9) showed 3-fold increases in dihydroethidine and dichlorodihydrofluorescein (CDCFH(2)) oxidation indicative of increased steady-state… (More)

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@article{Slane2006MutationOS, title={Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability.}, author={Benjamin G Slane and Nūkhet Aykin-Burns and Brian J. Smith and Amanda L. Kalen and Prabhat C. Goswami and Frederick E. Domann and Douglas R. Spitz}, journal={Cancer research}, year={2006}, volume={66 15}, pages={7615-20} }