Mutation of p53 gene in hepatocellular carcinoma in Taiwan.

@article{Sheu1992MutationOP,
  title={Mutation of p53 gene in hepatocellular carcinoma in Taiwan.},
  author={J. C. Sheu and Guan-Tarn Huang and Paul Haekyung Lee and Jade C. S. Chung and Hsiu Chu Chou and M. Y. Lai and J. T. Wang and Hye Seung Lee and Lichen Nancy Shih and Pei Ming Yang},
  journal={Cancer research},
  year={1992},
  volume={52 21},
  pages={6098-100}
}
To elucidate the role of p53 mutation in hepatocarcinogenesis in Taiwan, a hepatitis B viral infection hyperendemic area, exons 5 to 8 of the p53 gene in the tumor tissue of 61 hepatocellular carcinomas were amplified and sequenced. A total of 20 cases (32.8%) were found to have mutations; 36.6% (15 of 41) for the hepatitis B surface antigen positive group and 25.0% (5 of 20) for the hepatitis B surface antigen negative group. The corresponding normal liver showed no mutation. The mutation is… CONTINUE READING

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