Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy

@article{Sturm2003MutationOP,
  title={Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy},
  author={Isrid Sturm and Andrew G. Bosanquet and Sandra Hermann and Dilek G{\"u}ner and Bernd Doerken and Peter Ted Daniel},
  journal={Cell Death and Differentiation},
  year={2003},
  volume={10},
  pages={477-484}
}
AbstractInactivation of p53 has been shown to correlate with poor prognosis and drug resistance in malignant tumors. Nevertheless, few reports have directly shown such effects in primary tumor cells. Here, we investigated the p53 mutational status in 138 B-CLL samples and compared these findings with drug and γ-irradiation sensitivity profiles. p53 mutations resulted not only in a shorter survival but, notably also in selective resistance to alkylating agents, fludarabine and γ-irradiation. In… CONTINUE READING
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