Mutation of msh-2 in Neurospora crassa does not reduce the incidence of recombinants with multiple patches of donor chromosome sequence.

  title={Mutation of msh-2 in Neurospora crassa does not reduce the incidence of recombinants with multiple patches of donor chromosome sequence.},
  author={Lin Y Koh and David E. A. Catcheside},
  journal={Fungal genetics and biology : FG \& B},
  volume={44 7},
Meiotic Recombination in Neurospora crassa Proceeds by Two Pathways with Extensive Holliday Junction Migration
Analysis of thousands of Δmsh-2 octads using the authors' fluorescent recombination system indicates that, as in other filamentous fungi, symmetric heteroduplex is common in the his-3 region of Neurospora crassa, adding to evidence for a universal model for meiotic recombination.
Repeat-induced point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life
Neurospora crassa has the highest mutation rate and mutational burden of any non-viral life, and the majority of these coding sequence mutations appear not to be the direct product of RIP being mostly in non-duplicate sequence and predominantly not C→T mutations.
Molecular analysis of intragenic recombination at the tryptophan synthetase locus in Neurospora crassa
This sequence analysis has demonstrated that intragenic recombination is accurate to order mutations within one open reading frame and a leaky mutation was found to have a wild-type primary sequence.
DNA Repair and Recombination
Research into DNA repair and recombination can now proceed apace by deletion of each annotated gene with a predicted role in these processes, enabling to move beyond understanding individual repair systems to an understanding of more complex networks.


The msh2 Gene ofSchizosaccharomyces pombe Is Involved in Mismatch Repair, Mating-Type Switching, and Meiotic Chromosome Organization
The data show that besides having a function in mismatch repair, S. pombe msh2 is required for correct termination of copy synthesis during mating-type switching as well as for proper organization of chromosomes during meiosis.
Recombination events in Neurospora crassa may cross a translocation breakpoint by a template-switching mechanism.
It is suggested that template switching occurs in some recombination events, with repair synthesis alternating between use of the homolog and the initiating chromatid as template.
Mismatch repair in Schizosaccharomyces pombe requires the mutL homologous gene pms1: molecular cloning and functional analysis.
The mutant phenotypes are consistent with a general function of pms1 in correction of mismatched base pairs arising as a consequence of DNA polymerase errors during DNA synthesis, or of hybrid DNA formation between homologous but not perfectly complementary DNA strands during meiotic recombination.
Long, interrupted conversion tracts initiated by cog in Neurospora crassa.
It is suggested that the apparent association between conversion and crossing over at this locus may be due to confounding of coincidental events rather than to a mechanistic relationship.
Regulation of recombination at the his-3 locus in Neurospora crassa.
Summary The frequency of prototrophic recombination between pairs of his-3 alleles is increased in the absence of the dominant gene reo-w+, which is probably the same as reo-4+. The locus of reo-w is
The influence of the mismatch-repair system on stationary-phase mutagenesis in the yeast Saccharomyces cerevisiae
Study of the effects of deletions in genes encoding MutS- and MutL-related proteins on the reversion frequency of the lys2ΔBgl frameshift mutation suggests that MMR proteins, particularly MutS homologues, are involved in the control of mutability in stationary-phase yeast cells.
Alleles of the Hotspot cog Are Codominant in Effect on Recombination in the his-3 Region of Neurospora
It is shown that genetic background variation has at least a twofold effect on allelic recombination, together with the complexities of recombination in crosses bearing close mutant alleles, accounts for the previous conclusion that cog+ is dominant to cog.
Genes in Neurospora that suppress recombination when they are heterozygous.
It is proposed that ss (synaptic sequence) genes modulate recombination by determining the pairing closeness of DNA duplexes in the vicinity of the nit-2 locus.
Recombination at his-3 in Neurospora declines exponentially with distance from the initiator, cog.
It is concluded that recombination is initiated at cog(L) in >17% of meioses, that most conversion tracts are very short, and that few extend >14 kb, indicating that the extension of recombination events may be a stochastic process in most organisms.
The chromosomal region which includes the recombinator cog in Neurospora crassa is highly polymorphic
The St Lawrence ST74-OR23-IVA and Lindegren Y8743 strains of Neurospora crassa have a different provenance from wild collections and dissimilar cog alleles; that in Lindegren, cogLa previously