Mutation of lasA and lasB reduces Pseudomonas aeruginosa invasion of epithelial cells.

@article{Cowell2003MutationOL,
  title={Mutation of lasA and lasB reduces Pseudomonas aeruginosa invasion of epithelial cells.},
  author={Brigitte A. Cowell and Sally S. Twining and Jeffery A. Hobden and Mary S. F. Kwong and Suzanne M. J. Fleiszig},
  journal={Microbiology},
  year={2003},
  volume={149 Pt 8},
  pages={
          2291-9
        }
}
Pseudomonas aeruginosa is an opportunistic bacterial pathogen implicated in a variety of devastating conditions. Its flexibility as a pathogen is attributed to a myriad of virulence factors and regulatory elements that respond to prevailing environmental conditions. ExoS and ExoT are type III secreted effector proteins, regulated by the transcriptional activator ExsA, that can inhibit invasion of epithelial cells by cytotoxic strains of P. aeruginosa. This study sought to understand why… CONTINUE READING

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