Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase.


Site directed mutations of the C-methyltransferase domain of squalestatin tetraketide synthase were made in an attempt to alter the methylation pattern of the synthase expressed in vivo: mutation resulted in either no effect or in complete abrogation of polyketide production. 
DOI: 10.1039/b923990a


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