Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA.

  title={Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA.},
  author={Volker Schmieden and Jochen Kuhse and Heinrich Betz},
  volume={262 5131},
The amino acid at position 160 of the ligand-binding subunit, alpha 1, is an important determinant of agonist and antagonist binding to the glycine receptor. Exchange of the neighboring residues, phenylalanine at position 159 and tyrosine at position 161, increased the efficacy of amino acid agonists. Whereas wild-type alpha 1 channels expressed in Xenopus oocytes required 0.7 millimolar beta-alanine for a half-maximal response, the doubly mutated (F159Y,Y161F) alpha 1 subunit had an affinity… CONTINUE READING


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