Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.

@article{Yu2000MutationOC,
  title={Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.},
  author={Gengsheng Yu and Fusheng Chen and Masaki Nishimura and Harald Steiner and Anurag Tandon and T Kawarai and Shigeki Arawaka and Agnes Supala and You Qiang Song and Ekaterina A. Rogaeva and E. W. Holmes and Dong Zhang and Paul Milman and Paul E. Fraser and Christian Haass and Peter St George-Hyslop},
  journal={Acta neurologica Scandinavica. Supplementum},
  year={2000},
  volume={176},
  pages={6-11}
}
Presenilin (PS1 and PS2) holoproteins are transiently incorporated into low molecular weight (MW) complexes. During subsequent incorporation into a higher MW complex, they undergo endoproteolysis to generate stable N- and C-terminal fragments (NTF/CTF). Mutation of either of two conserved aspartate residues in transmembrane domains inhibits both presenilin… CONTINUE READING