Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice

Abstract

The development of characteristic visceral asymmetries along the left–right (LR) axis in an initially bilaterally symmetrical embryo is an essential feature of vertebrate patterning. The allelic mouse mutations inversus viscerum (iv) and legless (lgl) produce LR inversion, or situs inversus, in half of live-born homozygotes. This suggests that the iv gene… (More)
DOI: 10.1038/40140

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