Mutation of PIK3CA: possible risk factor for cervical carcinogenesis in older women.

@article{Cui2009MutationOP,
  title={Mutation of PIK3CA: possible risk factor for cervical carcinogenesis in older women.},
  author={Baoxia Cui and Biying Zheng and Xi Zhang and Ulf Stendahl and Sonia Andersson and K Wallin},
  journal={International journal of oncology},
  year={2009},
  volume={34 2},
  pages={409-16}
}
PIK3CA encodes the p110alpha catalytic subunit of PI 3-kinase, which regulates signaling pathways important for neoplasia, cell proliferation and apoptosis. Somatic mutations in this gene have been detected in several solid human tumors. We investigated these mutations in cervical carcinoma and its precursors, and their association with HPV infection and patient clinical data. The mutations were analyzed using post-PCR direct genomic DNA sequencing. Samples included 9 cervical cancer cell lines… CONTINUE READING

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