Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis.

@article{Wei2005MutationOL,
  title={Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis.},
  author={Chongjuan Wei and Christopher I. Amos and L. Clifton Stephens and Imelda M Campos and Jian Min Deng and Richard R. Behringer and A Rashid and Marsha L. Frazier},
  journal={Cancer research},
  year={2005},
  volume={65 24},
  pages={
          11297-303
        }
}
Peutz-Jeghers syndrome (PJS) is a dominantly inherited disorder characterized by gastrointestinal hamartomatous polyps and mucocutaneous melanin pigmentation. Germ line mutations in LKB1 cause PJS. We have generated mice carrying an Lkb1 exon 2 to 8 deletion by gene targeting in embryonic stem cells. Heterozygotes develop gastric hamartomas that are histologically similar to those found in humans with PJS. LKB1 is also reportedly a mediator of p53-dependent apoptosis. To explore the potential… CONTINUE READING

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