Mutation of FOXL2 in granulosa-cell tumors of the ovary.

  title={Mutation of FOXL2 in granulosa-cell tumors of the ovary.},
  author={Sohrab P. Shah and Martin K{\"o}bel and Janine Senz and Ryan D. Morin and Blaise Alexander Clarke and Kimberly C. Wiegand and Gillian P Leung and Abdalnasser Zayed and Erika Mehl and Steve E Kalloger and Mark Denne Sun and Ryan Giuliany and Erika Yorida and Steven Norman Jones and Richard Varhol and Kenneth D. Swenerton and Dianne Miller and Philip B. Clement and Colleen E Crane and Jason Madore and Diane Mich{\`e}le Provencher and Peter Leung and Anna DeFazio and Jaswinder S. Khattra and Gulisa Turashvili and Yongjun Zhao and Thomas Zeng and J N Mark Glover and Barbara C Vanderhyden and Chengquan Zhao and Christine A. Parkinson and Mercedes Jimenez-Linan and David D. L. Bowtell and Anne-Marie Mes-Masson and James D. Brenton and Sam Aparicio and Niki Boyd and Martin Hirst and C. Blake Gilks and Marco La Marra and David G. Huntsman},
  journal={The New England journal of medicine},
  volume={360 26},
BACKGROUND Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian sex cord-stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, their histopathological diagnosis can be challenging, and there is no curative treatment beyond surgery. METHODS We analyzed four adult-type GCTs using whole-transcriptome paired-end RNA sequencing. We identified putative GCT-specific mutations that were present in at least three of these samples but were absent from the… CONTINUE READING