Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease.

Abstract

Patients with cerebral small-vessel disease (CSVD) exhibit perturbed end-artery function and have an increased risk for stroke and age-related cognitive decline. Here, we used targeted genome-wide association (GWA) analysis and defined a CSVD locus adjacent to the forkhead transcription factor FOXC1. Moreover, we determined that the linked SNPs influence… (More)
DOI: 10.1172/JCI75109

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