Mutation of E1 glycoprotein of classical swine fever virus affects viral virulence in swine.

@article{Risatti2005MutationOE,
  title={Mutation of E1 glycoprotein of classical swine fever virus affects viral virulence in swine.},
  author={Guillermo R. Risatti and Lauren G. Holinka and Zhiqiang Lu and Gerald F. Kutish and Edan R. Tulman and Richard A. French and Jung H Sur and Daniel L Rock and Manuel V Borca},
  journal={Virology},
  year={2005},
  volume={343 1},
  pages={116-27}
}
Transposon linker insertion mutagenesis of a full-length infectious clone (IC) (pBIC) of the pathogenic classical swine fever virus (CSFV) strain Brescia was used to identify genetic determinants of CSFV virulence and host range. Here, we characterize a virus mutant, RB-C22v, possessing a 19-residue insertion at the carboxyl terminus of E1 glycoprotein. Although RB-C22v exhibited normal growth characteristics in primary porcine macrophage cell cultures, the major target cell of CSFV in vivo, it… CONTINUE READING

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