Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection.

@article{Dorman1998MutationIT,
  title={Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection.},
  author={Susan E. Dorman and Steven M Holland},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 11},
  pages={
          2364-9
        }
}

• Susan E. Dorman, Steven M Holland
• Published 1998 in The Journal of clinical investigation

IFN-gamma is critical in the immune response to mycobacterial infections, and deficits in IFN-gamma production and response have been associated with disseminated nontuberculous mycobacterial infections. Mutations in the IFN-gamma receptor ligand-binding chain (IFNgammaR1) have been shown to confer susceptibility to severe infection with nontuberculous mycobacteria. However, mutations in the IFN-gamma receptor signal-transducing chain (IFNgammaR2) have not been described. We describe a child… CONTINUE READING

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