Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickens.

@article{Tummala2006MutationIT,
  title={Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickens.},
  author={Hemanth Tummala and Manir Ali and P. J. Getty and Paul M Hocking and David W. Burt and Chris F. Inglehearn and Douglas H. Lester},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 11},
  pages={4714-8}
}
PURPOSE To identify the gene defect that causes blindness and the predisposition to embryonic death in the retinopathy globe enlarged (rge) chicken. METHODS Linkage analysis, with previously uncharacterized microsatellite markers from chicken chromosome 1, was performed on 138 progeny of an rge/+ and an rge/rge cross, and candidate genes were sequenced. RESULTS The rge locus was refined and the gene for guanine nucleotide-binding protein beta-3 (GNB3), which encodes a cone transducin beta… CONTINUE READING
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