Mutation in the P36 gene of Mycobacterium bovis provokes attenuation of the bacillus in a mouse model.

@article{Bigi2005MutationIT,
  title={Mutation in the P36 gene of Mycobacterium bovis provokes attenuation of the bacillus in a mouse model.},
  author={Fabiana Bigi and Andrea Karina Gioffr{\'e} and Laura In{\'e}s Klepp and Mar{\'i}a Paz Santangelo and C. A. Velicovsky and Guillermo H Giambartolomei and Carlos Alberto Fossati and Mar{\'i}a Isabel Romano and Tom A. Mendum and Jeffrey Mcfadden and Angel Cataldi},
  journal={Tuberculosis},
  year={2005},
  volume={85 4},
  pages={
          221-6
        }
}
P36 is a member of a family of secreted proteins distributed throughout the genus Mycobacterium. The central domain of these proteins contains several amino acid PGLTS repeats, which differ considerably between species. P36, also called exported repetitive protein (Erp) in M. tuberculosis, has been shown to be associated with virulence since the disruption of its gene impaired multiplication of both virulent M. tuberculosis and M. bovis BCG in cultured macrophages and immunocompetent mice. In… CONTINUE READING
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