# Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

@article{Polymeropoulos1997MutationIT,
title={Mutation in the $\alpha$-Synuclein Gene Identified in Families with Parkinson's Disease},
author={M. Polymeropoulos and C. Lavedan and E. Leroy and S. Ide and A. Dehejia and A. Dutra and B. Pike and H. Root and J. Rubenstein and R. Boyer and E. Stenroos and S. Chandrasekharappa and A. Athanassiadou and T. Papapetropoulos and W. Johnson and A. Lazzarini and R. Duvoisin and G. Iorio and L. Golbe and R. Nussbaum},
journal={Science},
year={1997},
volume={276},
pages={2045-2047}
}
Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence of approximately 2 percent. A pattern of familial aggregation has been documented for the disorder, and it was recently reported that a PD susceptibility gene in a large Italian kindred is located on the long arm of human chromosome 4. A mutation was identified in the α-synuclein gene, which codes for a presynaptic protein thought to be involved in neuronal plasticity, in the Italian kindred and in three… Expand
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