Mutation in murine coronavirus replication protein nsp4 alters assembly of double membrane vesicles.

Abstract

Coronaviruses are positive-strand RNA viruses that replicate in the cytoplasm of infected cells by generating a membrane-associated replicase complex. The replicase complex assembles on double membrane vesicles (DMVs). Here, we studied the role of a putative replicase anchor, nonstructural protein 4 (nsp4), in the assembly of murine coronavirus DMVs. We… (More)
DOI: 10.1016/j.virol.2008.01.018

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