Mutation in aging mice occurs in diverse cell types that proliferate postmutation.

@article{Fischer2008MutationIA,
  title={Mutation in aging mice occurs in diverse cell types that proliferate postmutation.},
  author={Jared M Fischer and James R. Stringer},
  journal={Aging cell},
  year={2008},
  volume={7 5},
  pages={667-80}
}
To determine the relationship between aging, cell proliferation and mutation in different cell types, hearts, brains and kidneys from G11 PLAP mice between 1 week and 24 months of age were examined. Mutant cells were detected in tissue sections by staining for Placental Alkaline Phosphatase (PLAP) activity, an activity that marks cells that have sustained a… CONTINUE READING