Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.

@article{Wang1997MutationIS,
  title={Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.},
  author={Dongmao Wang and Vicki E. Hammond and Helen E Abud and Ivan Bertoncello and John W. McAvoy and David D. L. Bowtell},
  journal={Genes & development},
  year={1997},
  volume={11 3},
  pages={309-20}
}
We have investigated the role of the mammalian Son of sevenless 1 (Sos1) protein in growth factor signaling in vivo by generating mice and cell lines that lacked the Sos1 protein. Homozygous null embryos were smaller than normal, died mid-gestation with cardiovascular and yolk sac defects, and their fibroblasts showed reduced mitogen-activated protein kinase activation in response to epidermal growth factor (EGF). An intercross of mice mutant for Sos1 and the EGF receptor (EGFR) demonstrated… CONTINUE READING

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