Mutation in ABCA1 predicted risk of ischemic heart disease in the Copenhagen City Heart Study Population.

OBJECTIVES We tested whether heterozygosity for the K776N mutation (frequency: 0.4%) in ATP-binding cassette transporter A1 (ABCA1) predicted ischemic heart disease (IHD) in the Copenhagen City Heart Study population. BACKGROUND In a complex trait like IHD, genetic variation is considered to be conferred by common DNA polymorphisms, although rare… CONTINUE READING