Mutation effects predicted from sequence co-variation

  title={Mutation effects predicted from sequence co-variation},
  author={Thomas A. Hopf and John B. Ingraham and Frank J. Poelwijk and Charlotta P I Sch{\"a}rfe and Michael Springer and Chris Sander and Debora S. Marks},
  journal={Nature Biotechnology},
Many high-throughput experimental technologies have been developed to assess the effects of large numbers of mutations (variation) on phenotypes. However, designing functional assays for these methods is challenging, and systematic testing of all combinations is impossible, so robust methods to predict the effects of genetic variation are needed. Most prediction methods exploit evolutionary sequence conservation but do not consider the interdependencies of residues or bases. We present… CONTINUE READING
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